Question

When cell has stalled DNA replication fork, which checkpoint should be predominantly activated?

पर्याय

• Both G₂/M and M

• G₁/S

• G₂/M

• M

Answer 1

G₂/M

Explanation:

The cell cycle has major checkpoints that examine cell size and chromosomal condition. These checkpoints deliver feedback signals that either activate or postpone succeeding phases of the cell cycle, allowing more time for the current phase to finish. In eukaryotic species, the G₂-M DNA damage checkpoint is a critical cell cycle checkpoint. This checkpoint ensures that cells do not enter mitosis before they have had a chance to repair damaged DNA following replication. Cells with a faulty G₂-M checkpoint undergo mitosis before fixing their DNA, resulting in cell death after division.