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Question
Aldehydes react with Grignard reagent to produce ____________.
Options
secondary alcohols
tertiary alcohols
primary alcohols
None of these
Solution
Aldehydes react with Grignard reagent to produce secondary alcohols.
Explanation:
The Grignard Reaction is the addition of an organomagnesium halide (Grignard reagent) to a ketone or aldehyde, to form tertiary or secondary alcohol, respectively. The reaction with formaldehyde leads to a primary alcohol.
Grignard Reagents are also used in the following important reactions:
The addition of an excess of a Grignard reagent to an ester or lactone gives tertiary alcohol in which two alkyl groups are the same, and the addition of a Grignard reagent to a nitrile produces an unsymmetrical ketone via a metalloimine intermediate.
\[\ce{RCHO + R1MgX -> RCH(OH)R1}\]
