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Question
Can you suggest any reason for the sigmoidal pattern of the oxygen dissociation curve?"
Solution
The sigmoidal pattern of oxygen haemoglobin dissociation curve is the result of two properties which play significant role in the transport of oxygen. These two properties are:
- Significant variations in oxygen tension occur above pO2 of 70–80 mm Hg, whereas minimal oxygen loss from haemoglobin occurs below. A comparatively flat area of the curve represents this.
- The haemoglobin releases a disproportionately larger amount of oxygen when the partial pressure drops below 40 mm Hg. It makes the curve sigmoid and causes the steeper part of the curve to occur.
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