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Question
Explain how the biochemical characterisation (nature) of 'Transforming Principle' was determined, which was not defined from Griffth's experiments.
Solution
Biochemical characterisation of transforming principle was determined by Oswald Avery, Colin Macleod, and Maclyn McCarty. They conducted a series of experiments to test the biochemical nature of genetic material. They purified various biochemicals (proteins, DNA, RNA, etc) from the heat-killed S cells to check which ones can transform the live R cells into S cells
These series of experiments suggested that DNA alone could transform the R cells into S cells. Thus they concluded that DNA is the hereditary material.
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