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Question
Explain the autoregulatory mechanism of GFR.
Solution
- The mechanism by which the kidney regulates the glomerular filtration rate is autoregulative. It is carried out by the juxtaglomerular apparatus.
- The juxtaglomerular apparatus is a microscopic structure located between the vascular pole of the renal corpuscle and the returning distal convoluted tubule of the same nephron.
- It plays a role in regulating the renal blood flow and glomerular filtration rate. When there is a fall in the glomerular filtration rate, it activates the juxtaglomerular cells to release renin.
- This stimulates the glomerular blood flow, thereby bringing the GFR back to normal. Renin brings the GFR back to normal by the activation of the renin-angiotensin mechanism.
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