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Question
Phenylketonuria arises due to genetic changes in ______ cells.
Options
liver
intestine
pancreas
heart
Solution
Phenylketonuria arises due to genetic changes in liver cells.
Explanation:
Phenylketonuria (PKU) is caused by a mutation in the gene that makes the enzyme phenylalanine hydroxylase, which is primarily active in the liver. This enzyme helps break down the amino acid phenylalanine. When it's missing or defective, phenylalanine builds up in the body, leading to PKU.
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