Advertisements
Advertisements
Question
What is the best reagent to convert nitrile to primary amine?
Solution
On treatment of nitriles with strong reducing agents such as lithium aluminium hydride in either of sodium metal in alcohol, primary amines are obtained.
\[\ce{\underset{Alkyl nitrile}{R - CN} + 4[H] ->[Na/C2H5OH][or LiAH4/ether] R - Cl2NH2}\]
APPEARS IN
RELATED QUESTIONS
Accomplish the following conversion:
Benzyl chloride to 2-phenylethanamine
Accomplish the following conversion:
Benzamide to toluene
Explain the mechanism of action of hydroiodic acid on 3-methylbutan-2-ol.
Identify the product 'A' in the following reaction.
\[\ce{Aniline ->[(CH3CO)2O][Pyridine] A}\]
Which nitrogen containing compound amongst the following would undergo Mendius reduction to furnish primary amine \[\ce{(R - NH2)}\]?
Reduction of aromatic nitro compounds using \[\ce{Fe}\] and \[\ce{HCl}\] gives ______.
Reduction of nitrobenzene by which of the following reagent gives aniline?
(i) \[\ce{Sn/HCl}\]
(ii) \[\ce{Fe/HCl}\]
(iii) \[\ce{H2 - Pd}\]
(iv) \[\ce{Sn/NH4OH}\]
Assertion: Only a small amount of \[\ce{HCl}\] is required in the reduction of nitro compounds with iron scrap and \[\ce{HCl}\] in the presence of steam.
Reason: \[\ce{FeCl2}\] formed gets hydrolysed to release \[\ce{HCl}\] during the reaction.
Which of the following reaction DOES NOT involve Hoffmann bromamide degradation?
Which of the following amines can be prepared by Gabriel phthalimide reaction?
