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प्रश्न
Who revealed biochemical nature of the transforming principle? How was it done?
उत्तर
Prior to the work of Oswald Avery, Colin MacLeod and Maclyn McCarty (1933 - 44), the genetic material was thought to be a protein. They worked to determine the biochemical nature of ‘transforming principle’ in Griffith’s experiment. They purified biochemicals (proteins, DNA, RNA, etc.) from the heat-killed S cells to see which ones could transform live R cells into S cells. They discovered that DNA alone from S bacteria caused R bacteria to become transformed.
They also discovered that protein-digesting enzymes (proteases) and RNA-digesting enzymes (RNases) did not affect transformation, so the transforming substance was not a protein or RNA. Digestion with DNase did inhibit transformation, suggesting that the DNA caused the transformation. They concluded that DNA is the hereditary material, but not all biologists were convinced.
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संबंधित प्रश्न
Give any two features of Genetic Code.
How did Hershey and Chase prove that DNA is the genetic material?
(a) Why did Hershey and Chase use radioactive 32P and 35S in their experiments? Explain.
(b) Following the experiments conducted by them, write what conclusion did they arrive at and how ?
Hershey and Chase experiment with bacteriophage showed that ____________.
Nucleotide arrangement in DNA can be seen by ______.
The scientists involved in discovery of DNA as chemical basis of heredity were ______.
The transforming principle of Pneumococcus as found out by Avery, MacLeod, and McCarty was ______.
Which of the following criteria must a molecule fulfill to act as genetic material?
- It should not be able to generate its replica.
- It should chemically and structurally be stable.
- It should not allow slow mutation.
- It should be able to express itself in the form of Mendelian Characters.
Which of the following methods of reproduction in bacteria involves participation of a virus?
Transformation was discovered by ______
