Advertisements
Advertisements
Question
Consult internet and find out how to make orally active protein pharmaceutical. What is the major problem to be encountered?
Solution
Orally active protein pharmaceuticals contain biologically active materials such as peptides or proteins, antibodies, and polymeric beads. It is administrated orally into the body through various formulations. It involves the encapsulation of protein or peptide in liposomes or formulations using penetration enhancers. These proteins or peptides are used for the treatment of various diseases and are also used as vaccines. However, the oral administration of these peptides or proteins has some problems related to it. Once these proteins are ingested, the proteases present in the stomach juices denature the protein. As a result, their effect will be nullified. Hence, it is necessary to protect the therapeutic protein from digestive enzymes, if taken orally. This is the reason for the proteins to be injected directly into the target site.
APPEARS IN
RELATED QUESTIONS
Why do children cured by enzyme-replacement therapy adenosine deaminase deficiency need periodic treatment?
Recombination DNA−technology is of great importance in the field of medicine. With the help of a flow chart, show how this technology has been used in preparing genetically engineered human insulins.
Can you suggest a method to remove oil (hydrocarbon) from seeds based on your understanding of rDNA technology and chemistry of oil?
State the cause of ADA deficiency in humans.Mention a possible cure for an ADA deficiency patient.
The genetic defect adenosine deaminase deficiency may be cured permanently by ____________.
PCR proceeds in three distinct steps governed by temperature, they are in order of ____________.
Which one of the following statements is true regarding DNA polymerase used in PCR?
ELISA technique is based on the principles of antigen-antibody interaction. Can this technique be used in the molecular diagnosis of a genetic disorder, such as phenylketonuria?
If a person thinks he is infected with HIV, due to unprotected sex, and goes for a blood test. Do you think a test such as ELISA will help? If so why? If not, why?
Human insulin is being commercially produced forma transgenic species of ______.
Choose the correct option regarding retrovirus.
Which is false about antibiotics?
ELISA is based on:
Now a days it is possible to detect the mutated gene causing cancer by allowing a radioactive probe to hybridize its complimentary DNA in a clone of cells, followed by its detection using autoradiography because ______
How is a mature, functional insulin hormone different from its prohormone form?
How is a mature, functional insulin hormone different from its prohormone form?
When a foreign DNA is introduced into an organism, how is it maintained in the host and how is it transferred to the progeny of the organism?
How does a gene therapy involving direct modification of the cells, in order to achieve a therapeutic goal is used in the treatment of ADA deficiency? Explain.
- Assertion: PCR is a powerful technique to identify genetic disorders.
- Reason: PCR can detect mutations in low amounts of DNA.
Give a reason for the following:
Streptokinase is administered to the patients having myocardial infarction.
