Advertisements
Advertisements
प्रश्न
Consult internet and find out how to make orally active protein pharmaceutical. What is the major problem to be encountered?
उत्तर
Orally active protein pharmaceuticals contain biologically active materials such as peptides or proteins, antibodies, and polymeric beads. It is administrated orally into the body through various formulations. It involves the encapsulation of protein or peptide in liposomes or formulations using penetration enhancers. These proteins or peptides are used for the treatment of various diseases and are also used as vaccines. However, the oral administration of these peptides or proteins has some problems related to it. Once these proteins are ingested, the proteases present in the stomach juices denature the protein. As a result, their effect will be nullified. Hence, it is necessary to protect the therapeutic protein from digestive enzymes, if taken orally. This is the reason for the proteins to be injected directly into the target site.
APPEARS IN
संबंधित प्रश्न
Expand the Given and mention one application of each:
ELISA
Give a schematic representation of the transformation of a pro-insulin into insulin.
How many amino acids are arranged in the two chains of Insulin?
Vaccines that use components of a pathogenic organism rather than the whole organism are called ____________.
Explain how ADA deficiency can be corrected?
The hormone insulin is secreted by:
ELISA is based on:
Now a days it is possible to detect the mutated gene causing cancer by allowing a radioactive probe to hybridize its complimentary DNA in a clone of cells, followed by its detection using autoradiography because ______
The Adenosine deaminase deficiency results in ______.
Why is it that the line of treatment for a genetic disease is different from infectious diseases?
Discuss briefly how a probe is used in molecular diagnostics.
Define Antigen and Antibody. Name any two diagnostic kits based upon them.
When a foreign DNA is introduced into an organism, how is it maintained in the host and how is it transferred to the progeny of the organism?
List the disadvantages of insulin obtained from the pancreas of slaughtered cows and pigs:
A host cell must be made competent, before it is able to receive an rDNA. Justify.
Explain how recombinant human insulin was prepared in 1983 by Eli Lily an American company.
- Assertion: PCR is a powerful technique to identify genetic disorders.
- Reason: PCR can detect mutations in low amounts of DNA.
In humans, somatic gene therapy was carried out to correct an immunodeficiency disease. Name this disease.
Give a reason for the following:
Streptokinase is administered to the patients having myocardial infarction.
