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प्रश्न
Explain how ADA deficiency can be corrected?
उत्तर
The right approach for SCID treatment would be to give the patient a functioning ADA which breaks down toxic biological products.
In some children ADA deficiency could be cured by bone marrow transplantation, where defective immune cells could be replaced with healthy immune cells from a donor. In some patients it can be treated by enzyme replacement therapy, in which functional ADA is injected into the patient.
During gene therapy the lymphocytes from the blood of the patient are removed and grown in a nutrient culture medium. A healthy and functional human gene, ADA cDNA encoding this enzyme is introduced into the lymphocytes using a retrovirus. The genetically engineered lymphocytes are subsequently returned to the patient. Since these cells are not immortal, the patient requires periodic infusion of such genetically engineered lymphocytes. The disease could be cured permanently if the gene for ADA isolated from bone marrow cells are introduced into the cells of the early embryonic stages.
संबंधित प्रश्न
Suggest any two possible treatments that can be given to a patient exhibiting adenosine deaminase deficiency.
State the role of C peptide in human insulin.
What is gene therapy? Illustrate using the example of adenosine deaminase (ADA) deficiency.
What is gene therapy? Name the first clinical case in which it was used.
Describe the steps that are followed during secondary treatment of sewage.
Answer the following question.
Describe the roles of heat, primers, and the bacterium Thermus aquaticus in the process of PCR.
Answer the following question.
Explain the various steps involved in the production of artificial insulin.
PCR proceeds in three distinct steps governed by temperature, they are in order of ____________.
ELISA is mainly used for ____________.
Vaccines that use components of a pathogenic organism rather than the whole organism are called ____________.
What are DNA vaccines?
Explain how recombinant Insulin can be produced.
Human insulin is being commercially produced forma transgenic species of ______.
ELISA is based on:
Which of the following is not an application of PCR (Polymerase Chain Reaction)?
With regard to insulin choose the correct options.
- C-peptide is not present in mature insulin.
- The insulin produced by rDNA technology has C-peptide.
- The pro-insulin has C-peptide.
- A-peptide and B-peptide of insulin are interconnected by disulphide bridges.
Choose the correct answer from the options given below.
Eli Lilly's contribution for diabetic patients through r-DNA technology has been overwhelmingly accepted. Explain how?
Give a reason for the following:
Streptokinase is administered to the patients having myocardial infarction.
How many cycles of PCR are required to produce 250 molecules of DNA, starting with a single parental strand?
