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Question
Explain Rh factor incompatibility during pregnancy.
Solution
The human beings who have antigen on RBCs are Rh+ while others who do not have are Rh. It is through Rh+ is dominated over Rh- which is recessive.
In a marriage between Rh– woman and Rh+ man, when a woman becomes pregnant, she becomes sensitive while carrying a first Rh+ child within her womb. It is because some of the RBCs from the developing embryo get into the blood stream of mother during development causing her to produce anti-Rh-antibodies. The first child of such parents is normal and is delivered safely. However, if such a mother get pregnant again the resulting Rh+ foetuses will be exposed to anti-Rh-bodies produced by the mother.
As a result serious damage to RBCs of the developing embryo will occur causing erythroblastosis foetilis. The disease leads to the death of the developing embryo before birth or after parturition.
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