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Question
How did the chemical nature of the ‘Transforming Principle' get established?
Solution
Oswald Avery, Colin MacLeod and Maclyn McCarty concluded that DNA is the hereditary material. They discovered that the protein-digesting enzymes (proteases) and RNA-digesting enzymes (RNases) did not affect transformation, so the transforming substance was not a protein or RNA. Digestion with DNase inhibits transformation; therefore, they concluded that DNA is the hereditary material.
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