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Question
What is recombination? Discuss the applications of recombination from the point of view of genetic engineering.
Solution
The formation of new combinations of genes, either by crossing over or independent assortment is called recombination. Alfred Sturtevant used the frequency of recombination between gene pairs on the same chromosome as a measure of the distance between genes and ‘mapped’ their position on the chromosome. Today genetic maps are extensively used as a starting point in the sequencing of whole genomes as was done in the case of the Human Genome Sequencing Project.
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RELATED QUESTIONS
Distance between the genes and percentage of recombination shows ______.
Occasionally, a single gene may express more than one effect. The phenomenon is called ______.
Discuss why Drosophila has been used extensively for genetical studies.
Assertion: When white eyed, yellow bodied Drosophila females were hybridized with red eyed, brown-bodied males; and F1 progeny was intercrossed, F2 ratio deviated from 9 : 3 : 3 : 1.
Reason: When two genes in a dihybrid are on the same chromosome, the proportion of parental gene combinations is much higher than the non-parental type.
