Question

Write a brief note. 

Monogenic disorders

Answer 1

Disorders or diseases occurring due to mutation in any single gene into a defective one are called monogenic disorders. Approximately 4000 different disorders of this type are now known. Due to abnormal genes, their products are either produced in insufficient quantity or not at all. It causes abnormal metabolism that may lead to death at a tender age. Examples of such disorders are Hutchinson’s disease, Tay-Sachs disease, galactosaemia, phenylketonuria, sickle cell anaemia, cystic fibrosis, albinism, haemophilia, night blindness, etc.