Drug-target Interaction - Enzymes as Drug Targets

Which site of an enzyme is called allosteric site?

How do enzymes catalyse a chemical reaction in the living system? Explain drug target interaction taking the example of enzyme as target.

Assertion: Non-competitive inhibitor inhibits the catalyic activity of enzyme by binding with its active site.

Reason: Non-competitive inhibitor changes the shape of the active site in such a way that substrate can’t recognise it.

Which of the following is not a target molecule for drug function in body?

Which of the following statements is not true about enzyme inhibitors?

Assertion: Enzymes have active sites that hold substrate molecule for a chemical reaction.

Reason: Drugs compete with natural substrate by attaching covalently to the active site of enzyme.

Assertion: Competitive inhibitors compete with natural substrate for their attachment on the active sites of enzymes.

Reason: In competitive inhibition, inhibitor binds to the allosteric site of the enzyme.

Name the macromolecules that are chosen as drug targets.