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Question
Discuss briefly, giving an example of the role of coordination compounds in medicinal chemistry.
Solution
There is growing interest in the use of chelate therapy in medicinal chemistry. An example is the treatment of problems caused by the presence of metals in toxic proportions in plant/animal systems. Thus, excess of copper and iron are removed by the chelating ligands D-penicillamine and desferrioxime B via the formation of coordination compounds. EDTA is used in the treatment of lead poisoning. Some coordination compounds of platinum effectively inhibit the growth of tumours. Examples are cis-platin and related compounds.
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