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Question
Give two examples of macromolecules that are chosen as drug targets
Solution
Enzyme and receptor are the macromolecules that are chosen as drug targets.
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What is the difference between agonists and antagonists?
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The most useful classification of drugs for medicinal chemists is ______.
Which of the following statements are incorrect about receptor proteins?
(i) Majority of receptor proteins are embedded in the cell membranes.
(ii) The active site of receptor proteins opens on the inside region of the cell.
(iii) Chemical messengers are received at the binding sites of receptor proteins.
(iv) Shape of receptor doesn’t change during attachment of messenger.
Where are receptors located?
How are receptor proteins located in the cell membrane?
Match the class of compounds given in Column I with their functions given in Column II.
| Column I | Column II |
| (i) Antagonists | (a) Communicate message between two neurons and that between neurons to muscles |
| (ii) Agonists | (b) Bind to the receptor site and inhibit its natural function |
| (iii) Chemical messenger | (c) Crucial to body’s communication process |
| (iv) Inhibitors | (d) Mimic the natural messenger |
| (v) Receptors | (e) Inhibit activities of enzymes |
Assertion: Receptors are crucial to body’s communication process.
Reason: Receptors are proteins.
Assertion: Chemical messenger gives message to the cell without entering the cell.
Reason: Chemical messenger is received at the binding site of receptor proteins.
Assertion: Receptor proteins show selectivity for one chemical messenger over the other.
Reason: Chemical messenger binds to the receptor site and inhibits its natural function.
