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Question
The most useful classification of drugs for medicinal chemists is ______.
Options
On the basis of chemical structure.
On the basis of drug action.
On the basis of molecular targets.
On the basis of pharmacological effect.
Solution
The most useful classification of drugs for medicinal chemists is on the basis of molecular targets.
Explanation:
The most useful classification of drugs for medicinal chemists. It is on the basis of molecular targets. Target molecules are usually biomolecules like carbohydrates, lipids, proteins and nucleic acids. These drugs possess some common structural features, may have the same mechanism of action on a specific drug target.
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Which of the following statements are incorrect about receptor proteins?
(i) Majority of receptor proteins are embedded in the cell membranes.
(ii) The active site of receptor proteins opens on the inside region of the cell.
(iii) Chemical messengers are received at the binding sites of receptor proteins.
(iv) Shape of receptor doesn’t change during attachment of messenger.
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How are receptor proteins located in the cell membrane?
Match the class of compounds given in Column I with their functions given in Column II.
| Column I | Column II |
| (i) Antagonists | (a) Communicate message between two neurons and that between neurons to muscles |
| (ii) Agonists | (b) Bind to the receptor site and inhibit its natural function |
| (iii) Chemical messenger | (c) Crucial to body’s communication process |
| (iv) Inhibitors | (d) Mimic the natural messenger |
| (v) Receptors | (e) Inhibit activities of enzymes |
Assertion: Receptors are crucial to body’s communication process.
Reason: Receptors are proteins.
Assertion: Chemical messengers are chemicals that enable communication of message between two neurons or between neurons and muscles.
Reason: Chemicals enter the cell through receptor.
Assertion: Chemical messenger gives message to the cell without entering the cell.
Reason: Chemical messenger is received at the binding site of receptor proteins.
