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Question
Best method for preparing primary amines from alkyl halides without changing the number of carbon atoms in the chain is ______.
Options
Hoffmann Bromamide reaction
Gabriel phthalimide synthesis
Sandmeyer reaction
Reaction with \[\ce{NH3}\]
Solution
Best method for preparing primary amines from alkyl halides without changing the number of carbon atoms in the chain is Gabriel phthalimide synthesis.
Explanation:
Gabriel phthalimide synthesis is used to get primary amine from alkyl halide without any change in number of carbon atoms.
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RELATED QUESTIONS
Write a short note on Hoffmann bromamide degradation.
Give the structure of A, B and C in the following reaction:
\[\ce{CH3CH2I ->[NaCN] A ->[OH-][Partial hydrolysis] B ->[NaOH + Br2] C}\]
Explain Hoffmann’s exhaustive alkylation with suitable reactions.
Identify 'A' and 'B' in the following conversions.
\[\ce{CH3 - I ->[Alc. KCN][\Delta] A ->[Na/C2H5OH] B}\]
Identify product B in the following reaction.
\[\ce{Aniline ->[NaNO2][HCl] A ->[KI] B}\]
Under which of the following reaction conditions, aniline gives p-nitro derivative as the major product?
(i) Acetyl chloride/pyridine followed by reaction with conc.\[\ce{H2SO4 }\] + conc. \[\ce{HNO3}\].
(ii) Acetic anyhdride/pyridine followed by conc.\[\ce{H2SO4}\] + conc.\[\ce{HNO3}\].
(iii) Dil. HCl followed by reaction with conc.\[\ce{H2SO4}\] + conc.\[\ce{HNO3}\].
(iv) Reaction with conc.\[\ce{HNO3}\] + conc.\[\ce{H2 SO4}\].
What is the best reagent to convert nitrile to primary amine?
Assertion: Hoffmann’s bromamide reaction is given by primary amines.
Reason: Primary amines are more basic than secondary amines.
Methyl amine on reaction with chloroform in the presence of NaOH gives ______.
Identify A and B in the following reaction.
\[\ce{C6H5CH2Br ->[Alco.][KCN] A ->[Na/Ethanol][reduction] B}\]
