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Question
Explain the formation of a nucleosome.
Solution
Komberg proposed a model for the nucleosome, in which 2 molecules of the four histone proteins H2A, H2B, H3, and H4 are organized to form a unit of eight molecules called histone octamere.
The negatively charged DNA is wrapped around the positively charged histone octamere to form a structure called a nucleosome. A typical nucleosome contains 200 bp of DNA helix. The histone octameres are in close contact and DNA is coiled on the outside of the nucleosome.
Nucleosome
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