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Question
Write a short note on the following:
Hoffmann’s bromamide reaction
Solution
Hoffmann developed a method for preparation of primary amines by treating an amide with bromine in an aqueous or ethanolic solution of sodium hydroxide. In this degradation reaction, migration of an alkyl or aryl group takes place from carbonyl carbon of the amide to the nitrogen atom. The amine so formed contains one carbon less than that present in the amide.
\[\begin{array}{cc}
\ce{O}\phantom{.............................................................}\\
||\phantom{.............................................................}\\
\ce{R - C - NH2 + Br2 + 4NaOH -> R - NH2 + Na2CO3 + 2NaBr + 2H2O}
\end{array}\]
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