Question

Assertion (A): In Thalassemia an abnormal myoglobin chain is synthesized due to a gene defect.

Reason (R): α-Thalassemia is controlled by genes HBA-1 and HBA-2 on chromosome 16.

Options

• Both (A) and (R) are true and (R) is the correct explanation of (A)

• Both (A) and (R) are true, but (R) is not the correct explanation of (A)

• (A) is true, but (R) is false

• (A) is false, but (R) is true

Answer 1

(A) is false, but (R) is true

Explanation:

Thalassemia is an autosomal recessive blood disorder caused by either variation or elimination, which ultimately results in a decreased rate of synthesis of one of the globin chains (α or β chains) that make up haemoglobin. Anaemia, a defining feature of the disease, results from the development of abnormal haemoglobin molecules as a result of this. The chain of the haemoglobin molecule that is imposed can help to categorise thalassemia. Production of the α-globin chain is impacted by α-thalassemia. The HBA-1 and HBA-2 genes on chromosome 16 of each parent regulate thalassemia, which is caused by mutation or deletion of one or more of the four genes.