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Question
What would be the molar concentration of human DNA in a human cell?
Solution
Molar concentration is the number of moles of solute in a solution divided by its volume, given in litres.
The average weight of a DNA base pair = 650 daltons (1 dalton equals the mass of a single hydrogen atom or 1.67 × 10-24 grams)
The molecular weight of a double-stranded DNA molecule = Total no. of base pairs × 650 daltons.
The human genome is 3.3 × 109 base pairs in length.
Hence, the weight of the human genome
= 3.3 × 109 base pair × 650 Daltons
= 3.59 × 10-12 gm.
The molar concentration of DNA can be calculated accordingly.
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