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प्रश्न
Answer the following
Explain Gabriel phthalimide synthesis.
उत्तर
This method is used for the synthesis of primary amine. It involves the following three stages.
i. Formation of the potassium salt of phthalimide from phthalimide on reaction with alcoholic potassium hydroxide.
ii. Formation of N-alkyl phthalimide from the potassium salt by reaction with an alkyl halide.
iii. Alkaline hydrolysis of N-alkyl phthalimide to form the corresponding primary amine.
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संबंधित प्रश्न
How are propan-1-amine and propan-2-amine prepared from oxime?
Write a short note on Hoffmann bromamide degradation.
Identify the compounds 'A' and 'B' in the following equation:
Write the chemical equation involved in the following reaction:
Hoffmann-bromamide degradation reaction
Illustrate the following reaction giving suitable example in each case:Gabriel phthalimide synthesis
An aromatic compound 'A' of molecular formula C7H7ON undergoes a series of reactions as shown below. Write the structures of A, B, C, D and E in the following reactions :
How do you convert the following: C6H5CONH2 to C6H5NH2
How do you convert the following: Ethanenitrile to ethanamine
Give the structures of A, B and C in the following reactions :
Give the structures of A, B and C in the following reaction:
Explain the mechanism of action of hydroiodic acid on 3-methylbutan-2-ol.
Mention 'two' uses of propan-2-one.
Identify 'A' and 'B' in the following reaction and rewrite the complete reaction :
Answer in one sentence.
Which amide does produce ethanamine by Hofmann bromamide degradation reaction?
Answer the following
Identify A and B in the following reactions.
\[\ce{C6H5CH2Br->[alco.][KCN]A ->[Na/ethanol]B.}\]
Write reactions to prepare ethanamine from Acetonitrile.
Write reactions to bring about the following conversions.
Acetamide to Ethylamine
Write reactions to bring about the following conversions.
Acetamide to methylamine
Explain Hoffmann’s exhaustive alkylation with suitable reactions.
Write reactions for the preparation of ethanamine using Gabriel phthalimide synthesis.
Why cannot aniline be prepared by Gabriel phthalimide synthesis?
Explain the following reaction with a suitable example.
Hofmann elimination reaction
Acetamide on reduction using Na/C2H5OH gives ____________.
Identify the major product (B).
\[\ce{CH3-CN ->[Na/C2H5OH]}\]
The product formed is ____________.
Identify 'A' and 'B' in the following conversions.
\[\ce{CH3 - I ->[Alc. KCN][\Delta] A ->[Na/C2H5OH] B}\]
Identify product B in the following reaction.
\[\ce{Aniline ->[NaNO2][HCl] A ->[KI] B}\]
Which of the following does NOT give carbylamine test?
Given below are two statements labelled as Assertion (A) and Reason (R).
Assertion (A): Alkyl halides are insoluble in water.
Reason (R): Alkyl halides have halogen attached to sp3 hybrid carbon.
Select the most appropriate answer from the options given below:
Benzylamine may be alkylated as shown in the following equation:
\[\ce{C6H5CH2NH2 + R - X -> C6H5CH2NHR}\]
Which of the following alkylhalides is best suited for this reaction through SN1 mechanism?
The source of nitrogen in Gabriel synthesis of amines is ______.
Amongst the given set of reactants, the most appropriate for preparing 2° amine is ______.
The best reagent for converting 2–phenylpropanamide into 2-phenylpropanamine is ______.
The best reagent for converting, 2-phenylpropanamide into 1- phenylethanamine is ______.
Hoffmann Bromamide Degradation reaction is shown by ______.
Reduction of aromatic nitro compounds using \[\ce{Fe}\] and \[\ce{HCl}\] gives ______.
The reagents that can be used to convert benzenediazonium chloride to benzene are:
(i) \[\ce{SnCl2/HCl}\]
(ii) \[\ce{CH3CH2OH}\]
(iii) \[\ce{H3PO2}\]
(iv) \[\ce{LiAlH4}\]
Which of the following amines can be prepared by Gabriel synthesis.
(i) Isobutyl amine
(ii) 2-Phenylethylamine
(iii) N-methylbenzylamine
(iv) Aniline
Write following conversions:
nitrobenzene `->` acetanilide
Write following conversions:
acetanilide `->` p-nitroaniline
How will you carry out the following conversions?
Match the reactions given in Column I with the statements given in Column II.
| Column I | Column II | ||
| (i) | Ammonolysis | (a) | Amine with lesser number of carbon atoms |
| (ii) | Gabriel phthalimide synthesis | (b) | Detection test for primary amines. |
| (iii) | Hoffmann Bromamide reaction | (c) | Reaction of phthalimide with \[\ce{KOH}\] and \[\ce{R-X}\] |
| (iv) | Carbylamine reaction | (d) | Reaction of alkylhalides with \[\ce{NH3}\] |
The compound X is which of the following?
\[\ce{CH3CN ->[Na + C2H5OH] x}\]
Ethylamine can be prepared by the action of bromine and caustic potash on which compound?
C6H5CONHCH3 can be converted into C6H5CH2NHCH3 by:-
Give reasons for the following:
Ammonolysis of alkyl halides is not a good method to prepare pure primary amines.
Which of the following amines can be prepared by Gabriel phthalimide reaction?
Which of the following would not be a good choice for reducing nitrobenzene to aniline?
Write short note on the following:
Ammonolysis
Identify A and B in the following reaction.
\[\ce{C6H5CH2Br ->[Alco.][KCN] A ->[Na/Ethanol][reduction] B}\]
Write the name of reduction product formed when ethyl cyanide is treated with sodium and alcohol.
Write short note on the following.
Ammonolysis.
Write a short note on the following:
Ammonolysis.
