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प्रश्न
Why cannot aniline be prepared by Gabriel phthalimide synthesis?
उत्तर
- Gabriel phthalimide synthesis is used for the preparation of aliphatic primary amines.
- It involves the nucleophilic substitution of alkyl halides by the anion formed by the phthalimide.
- But aryl halides do not undergo nucleophilic substitution with the anion formed by the phthalimide.
Hence, aniline cannot be prepared by Gabriel phthalimide synthesis.
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संबंधित प्रश्न
An aromatic compound 'A' of molecular formula C7H7ON undergoes a series of reactions as shown below. Write the structures of A, B, C, D and E in the following reactions :
Give the structures of A, B and C in the following reactions :
Accomplish the following conversions Nitrobenzene to benzoic acid
Accomplish the following conversions: Benzamide to toluene
Give the structures of A, B and C in the following reaction:
Give plausible explanation for each of the following :
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Answer in one sentence.
Which amide does produce ethanamine by Hofmann bromamide degradation reaction?
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Acetamide to methylamine
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\[\ce{Acetonitrile ->[Na/alcohol] A ->[NaNO2/dil.HCI] B}\]
The end product C of the following reaction is
\[\ce{C2H5NH2 ->[HNO2] A ->[PCl5] B ->[NH3][Alcohol] C}\]
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Quaternary ammonium salt is formed:
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(i) \[\ce{Sn/HCl}\]
(ii) \[\ce{Fe/HCl}\]
(iii) \[\ce{H2 - Pd}\]
(iv) \[\ce{Sn/NH4OH}\]
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Write following conversions:
acetanilide `->` p-nitroaniline
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| Column I | Column II | ||
| (i) | Ammonolysis | (a) | Amine with lesser number of carbon atoms |
| (ii) | Gabriel phthalimide synthesis | (b) | Detection test for primary amines. |
| (iii) | Hoffmann Bromamide reaction | (c) | Reaction of phthalimide with \[\ce{KOH}\] and \[\ce{R-X}\] |
| (iv) | Carbylamine reaction | (d) | Reaction of alkylhalides with \[\ce{NH3}\] |
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Reason: Primary amines are more basic than secondary amines.
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The Gabriels' phthalimide synthesis is used in the synthesis of
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\[\ce{CH3CN ->[Na + C2H5OH] x}\]
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Acetamide and ethyl amide can be distinguished by reacting with.
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Ammonolysis of alkyl halides is not a good method to prepare pure primary amines.
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Ammonolysis
Write short note on the following:
Ammonolysis
Write short notes on the following:
Ammonolysis
Write a short note on the following:
Ammonolysis
